Document Type

Article

Publication Date

2-2008

Publication Source

Tissue Engineering Part A

Abstract

Carbon-based materials are considered to be promising materials as implants because of their unique mechanical and biocompatibility properties. The current paper investigates the use of carbon-based materials as a functional interface for tissue scaffolds and medical implants. Three basic parameters were explored such as graphene orientation, crystallinity and surface interaction. To explore the effect of the orientation, samples were made with and without a preferred carbon orientation. Conversely, the crystallinity was studied using graphitic and carbonaceous matrices. Fluorescent, confocal and environmental scanning microscopy was used to visualize cell response. The cell attachment, proliferation and elongation were prevalent on the unidirectional carbon preform. It seems that the cells tended to orient parallel to the fiber axis (i.e. parallel to the 002 graphene plane) and proliferate as a function of higher crystallinity. In conclusion, the osteoblast (the bone-forming cells) attachment and growth rate is a function of carbon structure, more specifically, the crystallite size, graphene orientation and carbon graphitizability.

ISBN/ISSN

1937-3341

Document Version

Published Version

Publisher

Mary Ann Liebert

Volume

14

Issue

2

Peer Reviewed

yes

Keywords

Mary Ann Liebert Inc, Article, Endothelial-Cell Growth, Activated Carbon-Fibers, Surface-Roughness, Phenolic Resin, Carbon/Carbon Composites, Biological-Properties, Pyrolytic Carbon, Implant Material, Titanium-Alloy, Adhesion


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