Title

Eyeless Collaborates with Hedgehog and Decapentaplegic Signaling in Drosophila Eye Induction

Document Type

Article

Publication Date

4-2003

Publication Source

Developmental Biology

Abstract

eyeless (ey) is a key regulator of the eye development pathway in Drosophila. Ectopic expression of ey can induce the expression of several eye-specification genes (eya, so,and dac) and induce eye formation in multiple locations on the body. However, ey does not induce eye formation everywhere where it is ectopically expressed, suggesting that EY needs to collaborate with additional factors for eye induction. We examined ectopic eye induction by EY in the wing disc and found that eye induction was spatially restricted to the posterior compartment and the anterior–posterior (A/P) compartmental border, suggesting a requirement for both HH and DPP signaling. Although EY in the anterior compartment induced dpp and dac, these were not sufficient for eye induction. Coexpression experiments show that EY needs to collaborate with high level of HH and DPP to induce ectopic eye formation. Ectopic eye formation also requires the activation of an eye-specific enhancer of the endogenous hh gene.

Inclusive pages

49–61

ISBN/ISSN

0012-1606

Comments

Permission documentation is on file.

Publisher

Elsevier

Volume

256

Issue

1

Peer Reviewed

yes