Document Type

Article

Publication Date

5-2016

Publication Source

Neural Regeneration Research

Abstract

Alzheimer's disease (AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42 (Aß42) plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to (i) study etiology of disease, (ii) look for genetic modifiers, and (iii) identify chemical inhibitors that can block neurodegeneration and help to find cure for this disease. An insect model of Drosophila melanogaster has also provided new insights into the disease. Here we will discuss the utility of the Drosophila eye model to study Alzheimer's disease.

Inclusive pages

693-697

ISBN/ISSN

1673-5374

Document Version

Published Version

Comments

This document is provided for download in compliance with the publisher's open-access policies. Permission documentation is on file.

Publisher

Wolters Kluwer

Volume

11

Issue

5

Peer Reviewed

yes