Document Type
Article
Publication Date
9-17-2021
Publication Source
Antimicrobial Agents and Chemotherapy
Abstract
In vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime human-simulated regimens (HSR) against modified carbapenem inactivation method (mCIM)-positive Pseudomonas aeruginosa isolates harboring different OXA-10-like subtypes were described. The murine thigh model assessed ceftazidime (2 g every 8 h [q8h] HSR) and cefepime (2 g and 1 g q8h HSR). Phenotypes were similar despite possessing OXA-10-like subtypes with differing spectra. Ceftazidime produced ≥1-log10 killing in all isolates. Cefepime activity was dose dependent and MIC driven. This approach may be useful in assessing the implications of β-lactamase variants.
ISBN/ISSN
Print ISSN: 0066-4804; Online ISSN: 1098-6596
Document Version
Published Version
Publisher
American Society for Microbiology
Volume
65
Peer Reviewed
yes
Issue
10
Keywords
Pseudomonas aeruginosa, carbapenem resistant, cefepime, ceftazidime, in vivo, pharmacodynamics, pharmacokinetics
eCommons Citation
Tenover, Fred C.; Gill, Christian M.; Brink, Adrian; Chu, Chun Yat; Coetzee, Jennifer; Dimopoulos, George; Moodley, Clinton; Opperman, Christoffel Johannes; Pournaras, Spyros; Tickler, Isabella A.; Tootla, Hafsah Deepa; Vourli, Sophia; and Nicolau, David P., "Phenotypic/Genotypic Profile of Oxa-10-like-Harboring, Carbapenem-Resistant Pseudomonas aeruginosa: Using Validated Pharmacokinetic/Pharmacodynamic in Vivo Models to Further Evaluate Enzyme Functionality and Clinical Implications" (2021). Biology Faculty Publications. 359.
https://ecommons.udayton.edu/bio_fac_pub/359
Included in
Biology Commons, Biotechnology Commons, Cell Biology Commons, Genetics Commons, Microbiology Commons, Molecular Genetics Commons
Comments
This document is made available for download following a six-month embargo after publication date in compliance with the publisher’s open-access policy. Permission documentation is on file.
DOI: https://doi.org/10.1128/aac.01274-21