Purpose: It has been shown that after extracapsular lens removal by anterior capsulotomy in the mouse, the lens can be regenerated. However, as the capsular bag is filled with fibers, epithelial to mesenchymal transition (EMT), an event which is common after cataract surgery as well, takes place during early stages. This study, using a unique mouse model, was undertaken to identify novel regulators and networks in order to more clearly understand secondary cataracts at the molecular level.
Creative Commons Attribution, Non-Commercial, No Derivative Works License 3.0 (CC-BY-NC-ND)
Molecular Vision, Article, Sequence Tag Analysis, Posterior Capsule Opacification, Neibank Project, Cells, Transdifferentiation, Cataract, Model, Beta, Mice, Identification
Medvedovic, Mario; Tomlinson, Craig R.; Call, Mindy Kay; Grogg, Matthew; and Tsonis, Panagiotis A., "Gene Expression and Discovery During Lens Regeneration in Mouse: Regulation of Epithelial to Mesenchymal Transition and Lens Differentiation" (2006). Biology Faculty Publications. 8.