Title

Reductive Amination with Zinc Borohydride. Efficient, Safe Route to Fluorinated Benzylamines

Document Type

Article

Publication Date

1997

Publication Source

Synthetic Communications

Abstract

Fluorinated benzylamines are synthesized in high yields by reductive alkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptable to multigram-scale preparations.

Inclusive pages

4265-4274

ISBN/ISSN

0039-7911

Comments

Permission documentation is on file.

Publisher

Taylor & Francis

Volume

27

Issue

24

Peer Reviewed

yes