Reductive Amination with Zinc Borohydride. Efficient, Safe Route to Fluorinated Benzylamines
Fluorinated benzylamines are synthesized in high yields by reductive alkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptable to multigram-scale preparations.
Copyright © 1997, Informa UK
Taylor & Francis
Bhattacharyya, Sukanta; Chatterjee, Arindam; and Williamson, John S., "Reductive Amination with Zinc Borohydride. Efficient, Safe Route to Fluorinated Benzylamines" (1997). Office for Research Publications and Presentations. 11.