Title

O Dealkylation and Aliphatic and Aromatic Hydroxylation of 3-Methoxy-173-Estradiol by Aspergillus alliaceus

Document Type

Article

Publication Date

11-1989

Publication Source

Applied and Environmental Microbiology

Abstract

Aspergillus alliaceus UI 315 was examined for its ability to metabolize 3-methoxy-17 beta-estradiol. Preparative-scale incubations with this substrate afforded good yields of 6 beta-hydroxy-17 beta-estradiol, 4-hydroxy-17 beta-estradiol, and 4,6 beta-dihydroxy-17 beta-estradiol, which were identified by high-pressure liquid chromatography, 1H and 13C nuclear magnetic resonance, and high-resolution mass spectrometry.

Inclusive pages

3029-3031

ISBN/ISSN

0099-2240

Comments

Permission documentation is on file.

Publisher

American Society for Microbiology

Volume

55

Issue

11

Peer Reviewed

yes