Title

N-t-Boc-amino Acid Esters of Isomannide: Potential Inhibitors of Serine Proteases

Document Type

Article

Publication Date

10-2004

Publication Source

Amino Acids

Abstract

Hepatitis C, Dengue and West Nile virus are some of the most important flaviviruses, that share one important serine protease enzyme. Serine proteases are the most studied class of proteolytic enzyme and, in these cases, a primary target for drug discovery. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid esters derived of isomannide as potential serine proteases inhibitors.

Inclusive pages

153–159

ISBN/ISSN

0939-4451

Comments

Permission documentation is on file.

Publisher

Springer

Volume

27

Issue

2

Peer Reviewed

yes