Title

Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger

Document Type

Article

Publication Date

4-2004

Publication Source

Biotechnology Letters

Abstract

The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28 °C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l−1) to 15-hydroxy-10-deoxoartemisinin (26%) and 7β-hydroxy-10-deoxoartemisinin (69%).

Inclusive pages

607–610

ISBN/ISSN

0141-5492

Comments

Permission documentation is on file.

Publisher

Springer

Volume

26

Issue

7

Peer Reviewed

yes