Title

Efficient Synthesis of 4-oxo-4,5-dihydrothieno[3,2-cc]quinoline-2-carboxylic Acid Derivatives from Aniline

Document Type

Article

Publication Date

2-2014

Publication Source

Molecular Diversity

Abstract

The first reported synthesis of potential kinase inhibitors, 4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carboxylic acid derivatives starting from aniline is described. This efficient high yielding sequence was carried out in six steps without any chromatographic purification. A tandem nucleophilic aromatic substitution/cyclization reaction was used as a key step in the sequence. The versatile intermediate 2-carboxylic acid was used as a suitable precursor to access the functionalization of the C-ring, by convergent analog synthesis of several novel derivatives.

Inclusive pages

51–59

ISBN/ISSN

1381-1991

Comments

Permission documentation is on file.

Publisher

Springer

Volume

18

Issue

1

Peer Reviewed

yes