Title

Novel Peptide Mimetic Inhibitors of Hepatitis C Serine Protease Derived from Isomannide

Document Type

Article

Publication Date

2009

Publication Source

Synthesis

Abstract

Hepatitis C (HCV) infection is a cause of chronic liver disease such as cirrhosis, carcinoma, or liver failure, and the current therapy is effective in only 50% of patients. Serine proteases, which are present in HCV, are the most studied class of proteolytic enzymes­, and are a primary target in the drug development field. In this paper, we describe the synthesis and biological studies of a novel­ class of peptide mimetic compounds as potential HCV serine protease inhibitors.

Inclusive pages

620-626

ISBN/ISSN

0039-7881

Comments

Permission documentation is on file.

Publisher

Georg Thieme Verlag Stuttgart

Volume

4

Peer Reviewed

yes