Title

Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease

Document Type

Article

Publication Date

2006

Publication Source

Letters in Organic Chemistry

Abstract

New pseudopeptides possessing C2 symmetry and dihydroxyethylene core derived from (R,R)- tartaric acid and amino esters have been synthesized as potential inhibitors of HIV protease. The amino esters were chosen in order to interact with P1/P1 and P2/P2 subsites of the enzyme. The products were obtained in good yields without noticeable racemization.

Inclusive pages

882-886

ISBN/ISSN

1570-1786

Comments

Permission documentation is on file.

Publisher

Bentham Science Publishers

Volume

3

Issue

12

Peer Reviewed

yes