Single-Molecule Detection at High Concentrations with Optical Aperture Nanoantennas
Single-molecule detection has become an indispensable technology in life science, and medical research. In order to get meaningful information on many biological processes, single-molecule analysis is required in micro-molar concentrations. At such high concentrations, it is very challenging to isolate a single molecule with conventional diffraction-limited optics. Recently, optical aperture nanoantennas (OANs) have emerged as a powerful tool to enhance the single-molecule detection under a physiological environment. The OANs, which consist of nano-scale apertures on a metallic film, have the following unique properties: (1) nanoscale light confinement; (2) enhanced fluorescence emission; (3) tunable radiation pattern; (4) reduced background noise; and (5) massive parallel detection. This review presents the fundamentals, recent developments and future perspectives in this emerging field.
Copyright © 2016, Royal Society of Chemistry
Royal Society of Chemistry
Alam, Md Shah; Karim, Farzia; and Zhao, Chenglong, "Single-Molecule Detection at High Concentrations with Optical Aperture Nanoantennas" (2016). Physics Faculty Publications. 33.