Honors Theses

Author(s)

Gregory Versteeg

Advisor

Shawn Swavey

Department

Chemistry

Publication Date

Spring 4-2014

Document Type

Thesis

Abstract

With the goal of creating a porphyrin we reacted isoquinol pyrrole, p-fluorobenzaldehyde, and boron trifluoride etherate under appropriate conditions. Instead of a porphyrin being synthesized, we created polyisoquinol pyrrole in high yield and with great absorption properties around 600nm. We characterized this compound via UV/vis spectroscopy, proton NMR, and electrochemistry. The compound was then reacted with [Ru(bipy)2Cl2] to create a cationic compound and this molecule was tested as a possible photosensitizer for photodynamic therapy (PDT) but it was unable to photocleave plasmid DNA above 550nm. The original compound was then methylated and this new compound was also tested as a photosensitizer. This complex was successful at photocleaving DNA above 550nm and appears to be a promising photosensitizer.

Permission Statement

This item is protected by copyright law (Title 17, U.S. Code) and may only be used for noncommercial, educational, and scholarly purposes.

Disciplines

Chemistry | Physical Sciences and Mathematics


Included in

Chemistry Commons

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