Cell death is of key importance in maintaining health and normal development. In cancer, cell death is improperly controlled provoking uncontrolled proliferation of cells, which results in severe harm to the body. The Hippo pathway is an identified pathway in Drosophila melanogaster that is involved with regulating the different mechanisms of survival and proliferation within the cells. It is known to interact with a gene known as Dronc that is a key participant in the cell death pathway of apoptosis. Previous work has shown how the loss of certain caspases, which are cysteine proteases, is linked with cell survival. My project will be investigating the mechanism by which it happens, by testing the nature of the cell survival pathway. We hypothesize that the loss of function clones of drice, dronc, or dark promote cell proliferation that support tumor growth. At the conclusion of these studies, we expect to generate insights into how loss of cell death regulating genes impacts tissues, and if it promotes aggressive growth of cancer cells.
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Cancer Biology | Cell Biology
Hussain, Anam, "Drosophila Models to Investigate the Role of Regulation of Cell Death in Development and Cancer" (2016). Honors Theses. 86.