In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.
Creative Commons Attribution License (CC-BY)
Biomed Central Ltd, Review, X-Ray Analysis, Histone Fold, Crystal-Structure, Dna-Binding, Angstrom Resolution, Fourier Synthesis, Zinc Fingers, Complex Reveals, Oxygen-Affinity, Helix Domain
Sousounis, Konstantinos; Haney, Carl E.; Cao, Jin; Sunchu, Bharath; and Tsonis, Panagiotis A., "Conservation of the Three-Dimensional Structure in Non-Homologous Or Unrelated Proteins" (2012). Biology Faculty Publications. 10.