Tissue Engineering Part A
Carbon-based materials are considered to be promising materials as implants because of their unique mechanical and biocompatibility properties. The current paper investigates the use of carbon-based materials as a functional interface for tissue scaffolds and medical implants. Three basic parameters were explored such as graphene orientation, crystallinity and surface interaction. To explore the effect of the orientation, samples were made with and without a preferred carbon orientation. Conversely, the crystallinity was studied using graphitic and carbonaceous matrices. Fluorescent, confocal and environmental scanning microscopy was used to visualize cell response. The cell attachment, proliferation and elongation were prevalent on the unidirectional carbon preform. It seems that the cells tended to orient parallel to the fiber axis (i.e. parallel to the 002 graphene plane) and proliferate as a function of higher crystallinity. In conclusion, the osteoblast (the bone-forming cells) attachment and growth rate is a function of carbon structure, more specifically, the crystallite size, graphene orientation and carbon graphitizability.
This is a copy of an article published in Tissue Engineering Part A © 2008, copyright Mary Ann Liebert, Inc.
Mary Ann Liebert
Mary Ann Liebert Inc, Article, Endothelial-Cell Growth, Activated Carbon-Fibers, Surface-Roughness, Phenolic Resin, Carbon/Carbon Composites, Biological-Properties, Pyrolytic Carbon, Implant Material, Titanium-Alloy, Adhesion
Czarnecki, Jarema S.; Lafdi, Khalid; and Tsonis, Panagiotis A., "A Novel Approach to Control Growth, Orientation, and Shape of Human Osteoblasts" (2008). Biology Faculty Publications. 12.