Title

The Tumour-suppressor Genes NF2/Merlin and Expanded Act Through Hippo Signalling to Regulate Cell Proliferation and Apoptosis

Document Type

Article

Publication Date

1-2006

Publication Source

Nature Cell Biology

Abstract

Merlin, the protein product of the Neurofibromatosis type-2 gene, acts as a tumour suppressor in mice and humans. Merlin is an adaptor protein with a FERM domain and it is thought to transduce a growth-regulatory signal. However, the pathway through which Merlin acts as a tumour suppressor is poorly understood. Merlin, and its function as a negative regulator of growth, is conserved in Drosophila, where it functions with Expanded, a related FERM domain protein. Here, we show that Drosophila Merlin and Expanded are components of the Hippo signalling pathway, an emerging tumour-suppressor pathway. We find that Merlin and Expanded, similar to other components of the Hippo pathway, are required for proliferation arrest and apoptosis in developing imaginal discs. Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes.

Inclusive pages

27–36

ISBN/ISSN

1465-7392

Comments

Permission documentation on file.

Publisher

Nature Publishing Group

Volume

8

Peer Reviewed

yes

Issue

1


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