U.S. Patent and Trademark Office
The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, includ ing metabolic conditions.
Boettcher, Brian R.; Caplan, Shari L.; Daniels, Douglas S.; Geierstanger, Bernhard Hubert; Hamamatsu, Norio; Licht, Stuart; Loew, Andreas; and Weldon, Stephen Craig, "Patent: Methods of Treating FGF21-Associated Disorders" (2012). Chemistry Faculty Publications. 101.