Journal of the American Chemical Society
We recently reported that β-peptides can form discrete hetero-oligomers in aqueous solution. Here we describe the structure of such an oligomer as determined by X-ray crystallography. The structure of Zwit-1F reveals a homo-octamer of two cupped “hands” composed of both parallel and antiparallel 314-helices. The core of the assembly is composed entirely of solvent-excluded β3-homoleucine residues. The Zwit-1F assembly shares many of the physical characteristics of natural proteins.
Copyright © 2007 American Chemical Society
American Chemical Society
National Institutes of Health and the National Foundation for Cancer Research
Daniels, Douglas S.; Petersson, E. James; Qiu, Jade X.; and Schepartz, Alanna S., "High-Resolution Structure of a Beta-Peptide Bundle" (2007). Chemistry Faculty Publications. 89.