Document Type
Article
Publication Date
3-2012
Publication Source
Chemistry Central Journal
Abstract
Background: In this work the chemical structure of dextran-iron oxide thin films was reported. The films were obtained by MAPLE technique from composite targets containing 10 wt. % dextran with 1 and 5 wt.% iron oxide nanoparticles (IONPs). The IONPs were synthesized by co-precipitation method. A KrF* excimer laser source (λ = 248 nm, τFWHM≅25 ns, ν = 10 Hz) was used for the growth of the hybrid, iron oxide NPs-dextran thin films.
Results: Dextran coated iron oxide nanoparticles thin films were indexed into the spinel cubic lattice with a lattice parameter of 8.36 Å. The particle sized calculated was estimated at around 7.7 nm. The XPS shows that the binding energy of the Fe 2p3/2 of two thin films of dextran coated iron oxide is consistent with Fe3+ oxides. The atomic percentage of the C, O and Fe are 66.71, 32.76 and 0.53 for the films deposited from composite targets containing 1 wt.% maghemite and 64.36, 33.92 and 1.72 respectively for the films deposited from composite targets containing 5 wt.% maghemite. In the case of cells cultivated on dextran coated 5% maghemite γ-Fe2O3, the number of cells and the level of F-actin were lower compared to the other two types of thin films and control.
Conclusions: The dextran-iron oxide continuous thin films obtained by MAPLE technique from composite targets containing 10 wt.% dextran as well as 1 and 5 wt.% iron oxide nanoparticles synthesized by co-precipitation method presented granular surface morphology. Our data proved a good viability of Hep G2 cells grown on dextran coated maghemite thin films. Also, no changes in cells morphology were noticed under phase contrast microscopy. The data strongly suggest the potential use of iron oxide-dextran nanocomposites as a potential marker for biomedical applications.
Inclusive pages
1-12
ISBN/ISSN
1752-153X
Document Version
Published Version
Copyright
Copyright © 2012, Ciobanu et al.
Publisher
BioMed Central Ltd., part of Springer Science+Business Media
Volume
6
Peer Reviewed
yes
Issue
17
eCommons Citation
Ciobanu, Carmen Steluta; Iconaru, Simona Liliana; Gyorgy, Eniko; Radu, Mihaela; Costache, Marieta; Dinischiotu, Anca; Le Coustumer, Philippe; Lafdi, Khalid; and Predoi, Daniela, "Biomedical Properties and Preparation of Iron Oxide-Dextran Nanostructures by MAPLE Technique" (2012). Chemical and Materials Engineering Faculty Publications. 11.
https://ecommons.udayton.edu/cme_fac_pub/11
Included in
Other Chemical Engineering Commons, Other Materials Science and Engineering Commons, Polymer and Organic Materials Commons
Comments
This article has been archived and made available for download in compliance with publisher policy on self-archiving. It is licensed under the Creative Commons Attribution License 4.0 (CC-BY). Permission documentation is on file.