A Review on Pyrimidine-Based Derivatives: Synthesis and Their Biological Application
Document Type
Article
Publication Date
5-2024
Publication Source
Journal of Heterocyclic Chemistry
Abstract
Pyrimidine-based derivatives have attracted a lot of interest in heterocyclic chemistry due to its versatile structure and diverse biological activities. This study provides a comprehensive overview of synthetic strategy of different pyrimidine ring and highlights their biological importance. In this article, we start off by going through the fundamental procedures for the synthesis of pyrimidine scaffolds, including both conventional and contemporary synthetic techniques. These works cover a range of therapeutic domains, such as effects that are anticancer, antibacterial, antiviral, anti-inflammatory, antioxidant, antimalarial, and so on. Moreover, we have summarized with a discussion of future prospects and challenges in the field of pyrimidine heterocyclic chemistry. This thorough review is a significant resource for researchers in medicinal chemistry and related fields since it offers insightful information about the synthetic methods and biological applications of pyrimidine-based derivatives.
Inclusive pages
1159-1179
ISBN/ISSN
1943-5193
Volume
61
Peer Reviewed
yes
Issue
7
eCommons Citation
Islam, Md. Wahidul; Islam, Md. Monarul; Akter, Rabeya; Limon, Tayebur Rahman; Vasquez, Erick Salvador; Shaikh, Md. Aftab Ali; and Habib, Ahsan, "A Review on Pyrimidine-Based Derivatives: Synthesis and Their Biological Application" (2024). Chemical and Materials Engineering Faculty Publications. 241.
https://ecommons.udayton.edu/cme_fac_pub/241
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