Title

Chip Scale Tunable Nanosecond Pulsed Electric Field Generator for Electroporation

Author

Tchamie Kadja

Date of Award

1-1-2019

Degree Name

M.S. in Electrical Engineering

Department

Department of Electrical and Computer Engineering

Advisor/Chair

Advisor: Vamsy Chodavarapu

Abstract

Electroporation is a process that uses high voltage pulsed electric field to permeate cell membrane for drug infusion or cell death. Changing the voltage level, pulse period, or pulse width modifies the effect of the treatment. The purpose of this paper is to present a new alternative to high power pulsed field electric generators that, for the first time, reduces the system to a single custom complementary metal-oxide semiconductor (CMOS) chip, as well as allows various customizations in terms of frequency or duty cycle. A 206 kHz, 500V square wave was obtained from our chip design. The chip schematic simulation showed a duty cycle variation from 12.5% to 34.9%.

Keywords

Electrical Engineering, pulsed electric field, electric field generator, tunable, nanosecond, high power electric field, electroporation, system on chip, pulse period, pulse width, duty cycle, pulse frequency

Rights Statement

Copyright 2019, author

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