Chip Scale Tunable Nanosecond Pulsed Electric Field Generator for Electroporation
Date of Award
M.S. in Electrical Engineering
Department of Electrical and Computer Engineering
Advisor: Vamsy Chodavarapu
Electroporation is a process that uses high voltage pulsed electric field to permeate cell membrane for drug infusion or cell death. Changing the voltage level, pulse period, or pulse width modifies the effect of the treatment. The purpose of this paper is to present a new alternative to high power pulsed field electric generators that, for the first time, reduces the system to a single custom complementary metal-oxide semiconductor (CMOS) chip, as well as allows various customizations in terms of frequency or duty cycle. A 206 kHz, 500V square wave was obtained from our chip design. The chip schematic simulation showed a duty cycle variation from 12.5% to 34.9%.
Electrical Engineering, pulsed electric field, electric field generator, tunable, nanosecond, high power electric field, electroporation, system on chip, pulse period, pulse width, duty cycle, pulse frequency
Copyright 2019, author
Kadja, Tchamie, "Chip Scale Tunable Nanosecond Pulsed Electric Field Generator for Electroporation" (2019). Graduate Theses and Dissertations. 6719.