Title

Pathological image analysis with supervised and unsupervised deep learning approaches

Date of Award

2021

Degree Name

M.C.S. in Computer Science

Department

Department of Computer Science

Advisor/Chair

Tarek M. Taha

Abstract

Artificial intelligence (AI) based analysis is accelerating clinical diagnosis from pathological images and automating image analysis efficiently and accurately. Recently, Deep Learning (DL) algorithms have shown superior performance in pathological image analysis, such as tumor region identification, metastasis detection, and patient prognosis. As digital pathology becomes popular, it is crucial to evaluate the performance of DL approaches that show the best performance for the different color-space representations of pathological images. The main goal of this research is to analyze several supervised and unsupervised DL approaches in pathological image analysis. In this study, the Inception Residual Recurrent Convolutional Neural Network (IRRCNN) model has been examined in six different color spaces (RGB, CIE, HSB, YCrCb, Lab, and HSL) pathological images and evaluate the best color space for tissue classification tasks. In addition, the Recurrent Residual U-Net (R2U-Net) model is evaluated in six different color spaces images in nuclei segmentation tasks and selects the best color space. Also, R2U-Net based autoencoder models are examined for medical image denoising such as digital pathology, dermoscopy, Magnetic Resonance Imaging (MRI), and Computed Tomography (CT). The performance of the R2U-Net based auto-encoder model is also evaluated for the Transfer domain (TD) between MRI and CT scan images. Finally, as pathological images have higher dimensions, it is necessary to reduce the dimensionality for analyzing these samples by obtaining its original features representation in the lower dimensions. In this research, DL features have been extracted, and then the t-distributed Stochastic Non-linear Embedding (t-SNE) and Uniform Manifold Approximation and Projection (UMAP) are applied for clustering and visualization of pathological images.

Keywords

Biomedical Research, Computer Engineering, Computer Science, Artificial Intelligence, Medical Imaging, IRRCNN, R2UNet, UMAP, tSNE, digital pathology

Rights Statement

Copyright © 2021, author.

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