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At the end of the second millennium, John Paul II exhorted that, "The mission of Christ the Redeemer, which is entrusted to the Church, is still very far from completion." To renew the zeal of the missionary activity of Christians, he reminded those who are baptized, "Like the apostles after Christ's Ascension, the Church must gather us in the Upper Room together with Mary, the Mother of Jesus (Acts 1:14), in order to pray for the Spirit and to gain strength and courage to carry out the missionary mandate." Hence, in the missionary activity of the Church, there is a close link between the Holy Spirit, who is the principal agent of the mission and the response of a Christian missionary, a yes, like that of Mary at the Annunciation.