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The Eastern Newt, Notophthalamus viridescens, has regenerative abilities. This study delved into the ability of the newt to regenerate the lens of its eye from the iris following a lentectomy surgery. To regenerate, the dorsal and ventral regions of the iris dedifferentiate and proliferate, yet only the dorsal iris redifferentes to create a lens, rather than both the dorsal and ventral iris. Several candidate transposons, or sections of viral DNA incorporated into another organismâÂÂs genome, were selected from a transcriptome to study. In order to compare the differences between the dorsal and ventral irises, the candidate genesâ expression levels were monitored in regenerating lens at 0, 4, and 8 day time points following the surgery. The expression levels were compared to determine whether they are correlated with the regenerative ability. A further understanding of the newtâÂÂs regenerative abilities as a model organism could lead to groundbreaking advances in regenerative biology and medicine.

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Honors Thesis

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Panagiotis A. Tsonis

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Stander Symposium poster

Comparison of Notophthalamus viridescens Transposon Expression in the Dorsal and Ventral Iris during Lens Regeneration