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The Eastern Newt, Notophthalamus viridescens, has regenerative abilities. This study delved into the ability of the newt to regenerate the lens of its eye from the iris following a lentectomy surgery. To regenerate, the dorsal and ventral regions of the iris dedifferentiate and proliferate, yet only the dorsal iris redifferentes to create a lens, rather than both the dorsal and ventral iris. Several candidate transposons, or sections of viral DNA incorporated into another organismÃ¢ÂÂs genome, were selected from a transcriptome to study. In order to compare the differences between the dorsal and ventral irises, the candidate genesÃ¢ÂÂ expression levels were monitored in regenerating lens at 0, 4, and 8 day time points following the surgery. The expression levels were compared to determine whether they are correlated with the regenerative ability. A further understanding of the newtÃ¢ÂÂs regenerative abilities as a model organism could lead to groundbreaking advances in regenerative biology and medicine.
Panagiotis A. Tsonis
Primary Advisor's Department
Stander Symposium poster
Knape, Glenna M., "Comparison of Notophthalamus viridescens Transposon Expression in the Dorsal and Ventral Iris during Lens Regeneration" (2012). Stander Symposium Posters. 101.