The Effects of Structural Modi cation of the Wing Helix Domain of PriA on Bacterial DNA
Erich N Auer
During a cell’s life it must copy itself or face death. For the cell to form a new copy it must replicate its DNA, this DNA is the blueprint for the essential components of the cell. The replication process does not always go to completion, which is necessary for the cell to survive, so there are mechanisms to keep the replication process running smoothly. In bacteria, PriA is used to restart replication after damage to the DNA. By looking at the structure of PriA we can start to determine how exactly it works with the damaged DNA to fix it and restart the replication process. Specifically looking at the portion of PriA that attaches to DNA we are attempting to determine why this method of attachment is beneficial to the entire replication process. This is done by modifying the structure of PriA and observing the changes in DNA repair.
Honors Thesis - Undergraduate
Matthew E. Lopper
Primary Advisor's Department
Stander Symposium project
"The Effects of Structural Modi cation of the Wing Helix Domain of PriA on Bacterial DNA" (2017). Stander Symposium Projects. 1061.