Unravelling novel calcium-signaling mechanisms implicated in the neurobiology of learning and memory

Title

Unravelling novel calcium-signaling mechanisms implicated in the neurobiology of learning and memory

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Description

Calcium ions are potent regulators of cell fate, as they carry essential information from egg fertilization to cell death. Neuronal cells are no exception to this; calcium signals are critical for neuronal cell function and survival. Intrinsic calcium-cycling aberrations have a detrimental effect on neuronal cell fate, long-term potentiation , learning and memory. Subsequently, calcium signaling imbalances are associated with a wide range of debilitating neurolopsychiatric disorders whose pathophysiological mechanisms are elusive. Our group focuses on unravelling the regulatory mechanisms coupled to calcium handling in the central nervous system. Comprehensive studies have revealed that distribution of calcium in the cell is majorly regulated by the endoplasmic reticulum (ER), and hence the latter’s critical role in maintaining neuronal calcium homeostasis. We have recently identified a novel calcium-regulating protein expressed in the brain and we demonstrate for the first time, its implication in regulating learning and memory processes in the mouse brain. In the context of this presentation we will demonstrate overwhelming molecular and behavioral data to support the pivotal role of this novel calcium-regulating protein in the neurobiology of learning and memory.

Publication Date

4-18-2018

Project Designation

Graduate Research

Primary Advisor

Pothitos Pitychoutis

Primary Advisor's Department

Biology

Keywords

Stander Symposium poster

Comments

Presenters: Aikaterini Britzolaki, Joey Edward Saurine

Unravelling novel calcium-signaling mechanisms implicated in the neurobiology of learning and memory

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