A New Method in Organophosphate Synthesis
A variety of nucleophilic and Lewis acid catalysts were examined for use in promoting the synthesis of organophosphate triesters. All 8 organophosphate triesters are new compounds, reported here for the first time. MgSO4 was discovered as an inexpensive catalyst capable of improving the synthesis of a variety of aryl organophosphate triesters from the readily available and low cost precursor phosphorus oxychloride in a three-step, two-pot sequence. Yields for this method improve upon the uncatalyzed method by 8-36%. Although several chiral catalysts were tested, none were able to induce enantioselectivity in the reaction.
Jeremy M Erb
Primary Advisor's Department
Stander Symposium poster
"A New Method in Organophosphate Synthesis" (2018). Stander Symposium Posters. 1218.