A New Method in Organophosphate Synthesis
Emily Kathryn Granger, Kasia Maria Solomianko
A variety of nucleophilic and Lewis acid catalysts were examined for use in promoting the synthesis of organophosphate triesters. All 8 organophosphate triesters are new compounds, reported here for the first time. MgSO4 was discovered as an inexpensive catalyst capable of improving the synthesis of a variety of aryl organophosphate triesters from the readily available and low cost precursor phosphorus oxychloride in a three-step, two-pot sequence. Yields for this method improve upon the uncatalyzed method by 8-36%. Although several chiral catalysts were tested, none were able to induce enantioselectivity in the reaction.
Jeremy M. Erb
Primary Advisor's Department
Stander Symposium project
"A New Method in Organophosphate Synthesis" (2018). Stander Symposium Projects. 1218.