Modeling Bullying in Teenagers: Assessing the Behavioral Effects of Social Defeat Stress in Adolescent Mice
John Richard Coffey, Patrick Robert Flaherty
Depression, anxiety, and other stressed-induced cognitive deficits severely affect millions of people worldwide. Strikingly, an estimated one in four adolescents around the globe suffer from a mental health disorder. It has long been known that drastic developmental changes occur in the adolescent brain which makes teenagers far more susceptible to various stressors, most prominent being social and physical defeat from stronger peers (i.e., bullying). In order to investigate the behavioral effects of social defeat stress in adolescence, an adolescent mouse model was utilized. Adolescent mice were subjected to chronic resident-intruder stress and immediately following the completion of the paradigm, a battery of behavioral tests were conducted in order to assess levels of anxiety, depression, and cognitive flexibility.
Primary Advisor's Department
Stander Symposium project, College of Arts and Sciences
United Nations Sustainable Development Goals
Good Health and Well-Being
"Modeling Bullying in Teenagers: Assessing the Behavioral Effects of Social Defeat Stress in Adolescent Mice" (2020). Stander Symposium Projects. 1873.