Chronic Administration of the Novel SERCA2 Activator CDN1163 Induces Behavioral and Neurochemical Effects in Mice.
Intracellular calcium homeostasis is essential for neuronal function and survival, with the endoplasmic reticulum (ER) being a major internal calcium reservoir. Our group focuses on the sarco/endoplasmic reticulum (SR/ER) calcium (Ca2+)-ATPase (SERCA) pump that is a pivotal regulator of cytosolic calcium levels. Compelling evidence indicates that these P-type ATPases play a critical role in brain pathophysiology. Hence, SERCA pumps comprise an emerging pharmacological target for debilitating brain diseases. Interestingly, studies suggest that a novel SERCA activator, namely CDN1163, may rescue motor and cognitive dysfunction in rodent models of Alzheimer’s and Parkinson’s diseases. As little is known about the behavioral and neurochemical consequences of CDN1163 administration, in the context of this study, we are presenting the effects of acute and chronic CDN1163 administration on locomotor activity and relevant affective behaviors, as well as on monoaminergic neurotransmission in naïve C57BL/6J mice of both sexes.
Primary Advisor's Department
Stander Symposium project, College of Arts and Sciences
United Nations Sustainable Development Goals
Good Health and Well-Being
"Chronic Administration of the Novel SERCA2 Activator CDN1163 Induces Behavioral and Neurochemical Effects in Mice." (2021). Stander Symposium Projects. 2094.