Anuradha Chimata Venkatakrishnan, Summer Hope Jento



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Organogenesis is a fundamental process required to form organs. It requires axial patterning for the transition of monolayer of cells to an adult organ and involves the delineation of Anterior-Posterior (AP), Dorso-Ventral (DV), Proximo-Distal (PD) axes. Drosophila melanogaster is a great model to study this process because the genes and pathways are highly conserved in humans. During eye development, the DV axis is the first to form, and deviations during this process result in developmental birth defects. We have previously identified defective proventriculus (dve), a transcription factor as a dorsal selector gene that regulates wingless during eye development. Morphogens like wingless (wg), hedgehog (hh), and decapentaplegic (dpp) have important roles during eye development. The Hh pathway is highly conserved in mammals and has a role in growth and development. According to our hypothesis, dve interacts with Hedgehog signaling pathway during eye development and may have a role in eye vs. head fate specification. Using the Drosophila eye as a model, we study the interaction between dve and hh to understand the role of Hh signaling. We have used the GAL4-UAS bipartite system to modulate Hh signaling in the dve domain. We will be presenting the results from our initial studies. This study will further our understanding of patterning defects and the basis of genetic birth defects in the eye.

Publication Date


Project Designation

Independent Research

Primary Advisor

Amit Singh

Primary Advisor's Department



Stander Symposium project, College of Arts and Sciences

United Nations Sustainable Development Goals

Good Health and Well-Being

Studying the Interaction between Dorsal Patterning Gene Defective Proventriculus (dve) and Hedgehog Morphogen Signaling in Drosophila Eye Development