Direct polymerization of aliphatic bis-piperazine compounds and their non-antimicrobial properties
Emilie A. Moses
The piperazine functional group has found applications in the structure of novel antidepressants, chemotherapeutics, stimulants, and more recently as antimicrobial agents. Inclusion of piperazine in a material also leads to the chelation of metals (including toxic metals), which would have several environmental applications as fiber mats or bioengineering scaffolding materials. Thus, we synthesized the first aliphatic polyester polypiperazines directly from the Ti(IV) condensation of 1,4-bis(1-hexanol)piperazine with succinic acid. We characterized these novel polymeric materials using NMR, IR, and gel permeation chromatography. Since the biodegradation of these polymeric materials could lead to the release of a toxic by-product (the bis piperazine compounds), we analyzed the antimicrobial activities of the diol using AG100 E. coli as planktonic cultures (using the starting bis alcohols). We determined the antimicrobial activities using growth inhibition assays (with and without levofloxacin) as well as live/dead fluorescence staining of planktonic cells. We compared our growth inhibition results to 1-napthylmethylpiperazine and napthylmethylpiperazine derivatives. These collective data suggest polyester polypiperazines could be a novel thermoplastic, bioinert, biodegradable scaffolding material for tissue engineering and environmental applications.
Justin C. Biffinger, Matthew E. Lopper
Primary Advisor's Department
Stander Symposium project, College of Arts and Sciences
United Nations Sustainable Development Goals
Good Health and Well-Being; Responsible Consumption and Production
"Direct polymerization of aliphatic bis-piperazine compounds and their non-antimicrobial properties" (2022). Stander Symposium Projects. 2455.