Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice
Ben Klocke, Carter Moore
Calcium ions (Ca2+) in the brain play a vital role in prominent neurobiological functions, including neural communication, growth, long-term potentiation, and cell death. As a result, the regulation of Ca2+ levels in neurons is carefully managed, and Ca2+ dysregulation has been linked to various neuropsychiatric disorders including Alzheimer's disease, Parkinson's disease, and Schizophrenia. Herein, we sought to investigate how chronic pharmacological activation of an integral endoplasmic reticulum Ca2+-handling effector may affect learning and memory in the Morris Water Maze test in C57BL/6J mice of both sexes. In the context of the current honors thesis, we have gained insights into the relationship between intracellular Ca2+ homeostasis and learning and memory processes. Our efforts are currently targeted towards extending our findings in additional animal models of learning and memory.
Primary Advisor's Department
Stander Symposium, College of Arts and Sciences
Institutional Learning Goals
Scholarship; Practical Wisdom
"Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice" (2023). Stander Symposium Projects. 2853.