Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice

Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice

Presenter(s)

Ben Klocke, Carter Moore

Comments

Presentation: 1:40-2:00 p.m., Kennedy Union 207

Description

Calcium ions (Ca2+) in the brain play a vital role in prominent neurobiological functions, including neural communication, growth, long-term potentiation, and cell death. As a result, the regulation of Ca2+ levels in neurons is carefully managed, and Ca2+ dysregulation has been linked to various neuropsychiatric disorders including Alzheimer's disease, Parkinson's disease, and Schizophrenia. Herein, we sought to investigate how chronic pharmacological activation of an integral endoplasmic reticulum Ca2+-handling effector may affect learning and memory in the Morris Water Maze test in C57BL/6J mice of both sexes. In the context of the current honors thesis, we have gained insights into the relationship between intracellular Ca2+ homeostasis and learning and memory processes. Our efforts are currently targeted towards extending our findings in additional animal models of learning and memory.

Publication Date

4-19-2023

Project Designation

Honors Thesis

Primary Advisor

Pothitos Pitychoutis

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Institutional Learning Goals

Scholarship; Practical Wisdom

Effects of Chronic Pharmacological Modulation of SERCA in Learning and Memory Processes in Mice

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