Investigating the Role of Neural Stem Cells in Aggressive Gliomas
In the United States alone, there are more than 1.8 million people diagnosed with cancer every year. This number increases exponentially as the scope is expanded to look at the number of people affected worldwide (National Cancer Institute, 2020). With the widespread nature of cancer, treatments have been extensively researched and explored, but there is ultimately no cure for this aggressive and unrelenting disease. One extremely invasive type of cancer is Glioblastoma Multiforme (GBM), which is a specific type of brain cancer. The exact growth patterns of these tumors are unknown, but it is known that GBM is formed from excess glial stem cells, which are produced by neuroblasts. It is unsure whether these neuroblasts are preexisting in GBM tumors or if new neuroblasts are created to induce and promote GBM tumor metastasis. These aggressive tumors grow rapidly and aggressively, which makes their origins and pathways of growth extremely difficult to locate and track. The Drosophila melanogaster, or common fruit fly, is the model organism for this study. The power of Drosophila lies in the multiple genetic tools available for experimental design, and the conservation of genes and cell-biological processes between flies and humans (Portela et al., 2020), which means that findings from Drosophila studies can be easily verified in mammalian models and human patients. We have developed a GBM model in flies using the GAL4-UAS system, where two genotypically different flies will be crossed to induce these tumors in developing Drosophila larval brains. This study will explore the origins of GBM tumors and the nature of cell-biological and growth promoting pathways that promote uncontrolled growth of glial cells and neuroblasts within the brain.
Primary Advisor's Department
Stander Symposium, College of Arts and Sciences
"Investigating the Role of Neural Stem Cells in Aggressive Gliomas" (2023). Stander Symposium Projects. 2880.