Ruthenium-BODIPY Complexes as Potential Photodynamic Therapy Agents
Jake Swavey, Darcy Setter, Frederick Willits
Photodynamic therapy is a process by which light, a photosensitizer, and molecular oxygen are utilized to generate reactive oxygen species in a targeted microenvironment. The project presented will describe the synthesis of three new 4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dyes capable of strong absorption within the visible region of the spectrum. Incorporated within these dyes are conjugating Lewis Bases capable of coordinating to Ruthenium(II) complexes. There synthesis and characterization along with their ability to photo-react with plasmid DNA when irradiated with low energy light will be presented.
Primary Advisor's Department
Stander Symposium, College of Arts and Sciences
"Ruthenium-BODIPY Complexes as Potential Photodynamic Therapy Agents" (2023). Stander Symposium Projects. 3038.