Interaction between the dorsal selector gene defective proventriculus (dve) and Decapentaplegic (Dpp) signaling pathway during Drosophila eye development
Katie Perry, Anuradha Chimata Venkatakrishnan, Anjali Sangeeth; other authors: Neha Gogia, Madhuri Kango-Singh, Amit Singh 1,3,4,5,6
During organogenesis, axial patterning is required to establish the Antero-Posterior (AP), Dorso-Ventral (DV), and Proximo-Distal (PD) axes for proper organ development. The DV axis is thefirst lineage restriction event during eye development. These processes like patterning anddevelopment are carefully co-ordinated by various transcription factors, morphogens andsignalling pathways. Any errors in this process result in developmental defects, genetic birthdefects, and patterning defects in the organ. Here we wanted to study the interaction between apreviously identified dorsal selector gene defective proventriculus (dve, an ortholog of SATB1),a K-50 homeodomain containing transcription factor and Dpp morphogen. Decapentaplegic(Dpp)/Bone Morphogenetic Protein (BMP) signaling pathway is highly conserved in humans andforms morphogen gradient in the developing eye to initiate retinal differentiation and establishthe anterior-posterior axis of the Drosophila eye imaginal disc. We hypothesize that dve couldinteract with Dpp signaling and an optimum level of interaction between dve and Dpp signalingis essential for the proper development of Drosophila eye. Our results suggest Dve might interactin an antagonistic manner with Dpp pathway to regulate growth. We will address this hypothesisusing gain-of-function and loss-of-function approaches. Here we present how the dve patterninggene interacts with the Dpp signaling pathway to determine retinal vs head cuticle fate.
Amit Singh, Madhuri Kango-Singh
Primary Advisor's Department
Stander Symposium, College of Arts and Sciences
"Interaction between the dorsal selector gene defective proventriculus (dve) and Decapentaplegic (Dpp) signaling pathway during Drosophila eye development" (2023). Stander Symposium Projects. 3143.