Revealing the Dynamics of the Brain-Limb Axis During Limb Regeneration
Ben Klocke, Jason Tornes, Kaitlyn Martin, Augustine Miller; external collaborators include Dr. Katia Del Rio-Tsonis at Miami University (Oxford, Ohio) and Dr. Mario Looso at the Max Planck Institute for Heart and Lung Research (Bad Nauheim, Germany).
Complex tissue regeneration is an uncommon ability which can only be found in a small subset of vertebrates, with one of these being the amphibious axolotl, a salamander capable of regenerating its limbs following amputation. While the necessity of nerves in the process of limb regeneration has been well studied, the possible role of other components of the nervous system, such as the brain, is largely unknown. In the current study proteomics, gene expression and immunohistochemical approaches were employed to investigate changing protein expression patterns at various time-points throughout the process of limb regeneration. In the context of this presentation, we highlight intriguing neurobiological alterations that occur in the axolotl brain during limb regeneration, in an effort to shed light to the regulation of this fascinating physiological process.
Primary Advisor's Department
Stander Symposium, College of Arts and Sciences
Institutional Learning Goals
Scholarship; Practical Wisdom
"Revealing the Dynamics of the Brain-Limb Axis During Limb Regeneration" (2023). Stander Symposium Projects. 3197.