Immune Signaling by HCT-8 Cells in Response to Intracellular Pathogens
Viral infections have the potential to completely overwhelm the body if appropriate measures by the immune system are not taken. Under the mentorship of Dr. Sun and Dr. Rajput, my research focused on the influence of propionate (a metabolic byproduct of gut microbiota with putative health effects) on intestinal epithelium cells infected with coronavirus (OC 43). By studying the cytopathic effects of HCT-8 cells exposed to different concentrations of propionate, we were able to gain a better understanding of how the metabolism of our gut microbiota can modulate our immune functions, something that can potentially lead to the development of new treatment options for coronaviruses, including COVID-19.
Yvonne Sun, Mrigendra Rajput
Primary Advisor's Department
Stander Symposium, College of Arts and Sciences
Institutional Learning Goals
Scholarship; Practical Wisdom
"Immune Signaling by HCT-8 Cells in Response to Intracellular Pathogens" (2023). Stander Symposium Projects. 3251.