Presenter(s)

Malabika Bhowmik, Mychaela Janzow, Tooba Ahmed Momin

Comments

3:00-4:15, Kennedy Union Ballroom

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Description

Objective: Zinc finger proteins (ZFPs) are abundant in eukaryotic cells and play critical roles in cell signalling by binding to cellular components like DNA, RNA, lipids, and other proteins. Specifically, ZFP36L1 has been identified as a regulator of RNA metabolism with antiviral activity against multiple viruses. The current study aims to examine the role of ZFP36L1 in regulating norovirus replication using murine norovirus (MNoV-1) as a model. Given that viruses often hijack the autophagy pathway to facilitate replication, we also seek to understand the relationship between ZFP36L1’s antiviral efficacy and autophagy modulation.

Publication Date

4-23-2025

Project Designation

Graduate Research

Primary Advisor

Mrigendra Rajput

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Institutional Learning Goals

Scholarship; Community; Scholarship

ZFP36L1 negatively regulates autophagy to suppress murine norovirus replication

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