Investigating Key Features of Multifocal and Multicentric Breast Cancer via Model-On-A-Chip

Investigating Key Features of Multifocal and Multicentric Breast Cancer via Model-On-A-Chip

Presenter(s)

Anh Nguyen, Anna Marie Schmitz

Comments

3:00-4:15, Kennedy Union Ballroom

Description

Multifocal (MF) and multicentric (MC) breast cancers are defined as synchronous, ipsilateral breast cancers that are more aggressive than their unifocal counterparts, and are known for having lower survival rates, higher recurrence, and lymph node metastasis. Previously, researchers have focused on distinct biological features of MF/MC breast cancers, including genetic alterations and clonality. Yet, the mechanisms dictating occurrence and tumor transformation of MF/MC breast cancer is not fully understood. Our lab has identified the gene signatures of MF/MC breast cancer via analyzing published datasets and developed a 3D lab-on-chip model to simulate the MF/MC breast cancers microenvironment for further experimental studies. This research poster explores MF/MC breast cancer through spheroid responses (sprouting cells and spheroid movements) in chessboard-like PDMS on-chip models. We have successfully generated a 3D MF/MC breast cancer model that evaluates the potential of multi-spheroid studies. In the future, we aim to generate spheroids with different breast cancer cell lines to represent heterozygous MF/MC breast cancer tumors.

Publication Date

4-23-2025

Project Designation

Independent Research

Primary Advisor

Loan T. Bui, Thanh Lan Chu

Primary Advisor's Department

Biology

Keywords

Stander Symposium, College of Arts and Sciences

Institutional Learning Goals

Scholarship

Investigating Key Features of Multifocal and Multicentric Breast Cancer via Model-On-A-Chip

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