
Investigating Key Features of Multifocal and Multicentric Breast Cancer via Model-On-A-Chip
Presenter(s)
Anh Nguyen, Anna Marie Schmitz
Files
Description
Multifocal (MF) and multicentric (MC) breast cancers are defined as synchronous, ipsilateral breast cancers that are more aggressive than their unifocal counterparts, and are known for having lower survival rates, higher recurrence, and lymph node metastasis. Previously, researchers have focused on distinct biological features of MF/MC breast cancers, including genetic alterations and clonality. Yet, the mechanisms dictating occurrence and tumor transformation of MF/MC breast cancer is not fully understood. Our lab has identified the gene signatures of MF/MC breast cancer via analyzing published datasets and developed a 3D lab-on-chip model to simulate the MF/MC breast cancers microenvironment for further experimental studies. This research poster explores MF/MC breast cancer through spheroid responses (sprouting cells and spheroid movements) in chessboard-like PDMS on-chip models. We have successfully generated a 3D MF/MC breast cancer model that evaluates the potential of multi-spheroid studies. In the future, we aim to generate spheroids with different breast cancer cell lines to represent heterozygous MF/MC breast cancer tumors.
Publication Date
4-23-2025
Project Designation
Independent Research
Primary Advisor
Loan T. Bui, Thanh Lan Chu
Primary Advisor's Department
Biology
Keywords
Stander Symposium, College of Arts and Sciences
Institutional Learning Goals
Scholarship
Recommended Citation
"Investigating Key Features of Multifocal and Multicentric Breast Cancer via Model-On-A-Chip" (2025). Stander Symposium Projects. 3900.
https://ecommons.udayton.edu/stander_posters/3900

Comments
3:00-4:15, Kennedy Union Ballroom