Efficient Light-Induced Reactive Oxygen Species Production from a Cationic Mitochondrial-Targeting BODIPY Dye.

Efficient Light-Induced Reactive Oxygen Species Production from a Cationic Mitochondrial-Targeting BODIPY Dye.

Presenter(s)

Cynthia Bukirwa

Comments

1:20-1:40, Kennedy Union 222

Description

Efficient Light-Induced Reactive Oxygen Species Production from a Cationic Mitochondrial-Targeting BODIPY Dye. Cynthia Bukirwa (Undergraduate student), Dr. Shawn Swavey (Professor, Department of Chemistry, University of Dayton)BODIPY dyes have demonstrated their effectiveness as photosensitizers due to their diverse reactivity and high selectivity. These dyes are highly versatile and can be modified to absorb light across the visible and infrared spectrum. This study introduces a red light-activated BODIPY dye capable of subcellular localization within the mitochondria, yielding high quantum yields of reactive oxygen species (ROS). The potential of this dye to serve as a photodynamic therapy (PDT) agent highlights its promise as an organelle-targeted phototherapeutic. The synthetic route for this dye, along with its characterization and evaluation through 1H NMR, electronic absorption spectroscopy, and fluorescence spectroscopy, is detailed. The dye's ability to generate singlet oxygen and superoxide radicals, as well as its capacity to photo-nick plasmid DNA, will also be addressed. Integrating this organelle-targeted strategy into cancer treatment therapies could help mitigate drug resistance and reduce the recurrence of tumor cells.

Publication Date

4-23-2025

Project Designation

Honors Thesis

Primary Advisor

Shawn M. Swavey

Primary Advisor's Department

Chemistry

Keywords

Stander Symposium, College of Arts and Sciences

Efficient Light-Induced Reactive Oxygen Species Production from a Cationic Mitochondrial-Targeting BODIPY Dye.

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