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My research focused on the repair and replication of damaged DNA in the Deinococcus radiodurans (D. rad) bacteria, which is able to survive extreme levels of DNA damage with no detriment to its health because it is very efficient at repairing damaged DNA. In replicating (copying) bacterial DNA, damaged DNA will cause the replication to stop. This requires the DNA replication to be restarted in order for replication to be completed and cell death avoided. In most bacteria the proteins that function to restart DNA replication at points of DNA damage are fairly well conserved from bacteria to bacteria; however the D.rad bacteria lacks many of those proteins. I investigated the interactions between the proteins in this pathway that D. rad bacteria has, resulting in a clearer understanding of how these proteins interact in the D. rad replication restart pathway.
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Ryan, Mike, "Investigating DNA Repair Processes in Bacteria: Can D. rad PriA load D. rad DnaB onto DNA forks with a leading strand gap?" (2014). Stander Symposium Posters. 468.
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