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Many genes in the Drosophila melanogaster have Pol II paused at the promoter proximal region, because the binding of either the GAGA factor or the Motif 1 binding protein (M1BP). M1BP is highly conserved across the species and encodes a 55kDa protein containing five C2H2 zinc-fingers domains. Drosophila eye development is regulated by a battery of highly conserved genes. Based on high throughput studies, it has been suggested that M1BP may regulate gene expression during Drosophila eye development, but its exact role is unknown. Our aim is to study the role of M1BP during eye development. We found that absence of M1BP function in dorsal and ventral eye margins results in the suppression of eye fate and the suppression of the gene from the complete eye gives us a head loss phenotype

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Honors Thesis

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Amit Singh

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Stander Symposium poster

The Role of M1BP in Eye Development of Drosophila Melanogaster