Magnesium Catalyzed Synthesis of Organophosphates
Emily K Granger, Cori K Young
Synthetic strategies for the construction of phosphorus centered organophoshorus molecules are underdeveloped compared to their carbon-centered cousins. Though the methods for the construction of organophosphate triesters and their derivatives are somewhat limited, they nevertheless have recently found great utility in the pharmaceutical industry. Given that phosphates are commonly used by nature as powerful tools for the regulation of life processes, it is no surprise to find them as key components in many pharmaceuticals.6 It is easy to find phosphorylation and dephosphorylation in reactions that control various aspects of metabolism through phosphate esters or their derivatives. This type of chemistry offers profound control with biomolecules such as proteins (especially kinases), carbohydrates, nucleotides (DNA and RNA), and steroids. As such it is a process that, when controlled, can treat many different types of human ailments such as cancer, contagious diseases like Hepatitis C, AIDS, and the flu
Independent Research - Undergraduate
Primary Advisor's Department
Stander Symposium project
"Magnesium Catalyzed Synthesis of Organophosphates" (2017). Stander Symposium Projects. 854.