Jayne B. Robinson Ph.D.
Antimicrobial photodynamic therapy (PDT) utilizing porphyrins has emerged as a possible ancillary treatment against antibiotic resistant bacteria. Porphyrins, such a novel zinc containing porphyrin designated ZnP, create reactive oxygen species that are toxic to bacterial cells utilizing light by a mechanism that is not yet fully understood. Previous experiments have shown ZnP to be able to kill microorganisms in the dark which is unique to few porphyrins. The aim of this research is to understand the effect ZnP has on Mycobacterium smegmatis, a model organism for the pathogenic bacterium Mycobacterium tuburculosis which causes the lung infection tuberculosis. Further experimentation is to include understanding the effects of ZnP on M. smegmatis biofilm formation and disruption as well as antibiotic uptake in formerly antibiotic resistant cells.
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Biology | Life Sciences
Jama, Marissa C., "Effectiveness of a Novel Porphyrin Exhibiting Dark Toxicity against the Model Organism Mycobacterium smegmatis" (2017). Honors Theses. 115.