Honors Theses

Author(s)

Alexander Hayes

Advisor

Yvonne Sun, Ph.D.

Department

Biology

Publication Date

4-1-2019

Document Type

Honors Thesis

Abstract

Listeria monocytogenes is a gram-positive bacillus that is commonly associated with foodborne illness. It is a facultative intracellular pathogen responsible for causing the listeriosis infection in humans which is particularly dangerous to immunocompromised individuals. L. monocytogenes pathogenesis occurs through a series of complex interactions between host and bacterial cellular machinery. The wild-type strain as well as a cardiotropic strain with high affinity for infecting cardiac tissue were used to investigate pathogenesis in L. monocytogenes. Specifically, the Listeriolysin O protein that is critical for virulence was investigated. Aerobic and anaerobic growth environments as well as short-chain fatty acid supplementation were utilized to understand how growth conditions affect the pathogenic ability of L. monocytogenes.

Permission Statement

This item is protected by copyright law (Title 17, U.S. Code) and may only be used for noncommercial, educational, and scholarly purposes

Disciplines

Biology


Included in

Biology Commons

Share

COinS