Yvonne Sun, Ph.D.
Listeria monocytogenes is a gram-positive bacillus that is commonly associated with foodborne illness. It is a facultative intracellular pathogen responsible for causing the listeriosis infection in humans which is particularly dangerous to immunocompromised individuals. L. monocytogenes pathogenesis occurs through a series of complex interactions between host and bacterial cellular machinery. The wild-type strain as well as a cardiotropic strain with high affinity for infecting cardiac tissue were used to investigate pathogenesis in L. monocytogenes. Specifically, the Listeriolysin O protein that is critical for virulence was investigated. Aerobic and anaerobic growth environments as well as short-chain fatty acid supplementation were utilized to understand how growth conditions affect the pathogenic ability of L. monocytogenes.
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Hayes, Alexander, "Pathogenic Differences in Listeria monocytogenes 10403s and Cardiotropic Strains Grown under Aerobic and Anaerobic Conditions" (2019). Honors Theses. 215.