Matthew Lopper, Ph.D.
Antibiotic resistance is a constantly progressing epidemic. Many strains of bacteria have developed a resistance to antibiotics, resulting in prolonged sickness and death. Resistance can be to a specific drug (single drug resistance) or to multiple drugs (multi-drug resistance). This resistance can be caused by a tripartite protein pump called an efflux pump that extends through the inner and outer membranes of the bacterium to pump antibiotics from the inside of the cell to the extracellular environment. In E. coli the efflux pump is called AcrAB-TolC. In the efforts to combat this problem, this experiment focuses on the inactivation of the AcrAB-TolC pump via organic compounds extracted from edible plants. Extracts from plants, nuts, and roots will be tested for their ability to inhibit the bacterial efflux pump. I hypothesize that naturally occurring compounds can block the activity of this pump and combat antibiotic resistance.
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Therriault, Marrisa, "Identifying Natural Inhibitors of Bacterial Efflux Pumps" (2019). Honors Theses. 239.