Kristen Krupa Comfort
Chemical and Materials Engineering
Due to their unique physicochemical properties, nanoparticle (NP)-based technologies are growing exponentially in scope and economic importance. This has created a vital need to fully understand the potential biological consequences of NP exposure, characterize resulting NP-biological interfaces, and determine subsequent toxicological effects. The goal of this research project is to design an enhanced microenvironment model (EMM) that combines the advantages of in vitro and in vivo physiological models to evaluate NP characteristics under physiologically relevant conditions. An EMM was constructed that incorporates multiple cell lines, an immune system component, and physiologically relevant flow conditions. This model was tested for AgNP deposition, cellular viability, and immune responses and compared to the typical in vitro physiological model. Overall interpretation of the results supports the use of an EMM for cellular response characterization.
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Jewett, Maggie, "Design of an Enhanced Cellular Model for the Assessment and Tracking of Nanomaterials" (2020). Honors Theses. 261.
Embargoed until Sunday, June 23, 2120