Honors Theses


Karolyn Hansen and Jayne Robinson



Publication Date


Document Type

Honors Thesis


Within recent years there have been a growing number of antibiotic resistant bacterial strains. Many of these strains produce biofilms, which are sturdy layers of bacteria on a surface. Biofilms often form layers on surfaces which can prevent typical antibiotic treatment methods from being effective. In recent years the novel porphyrin, Zinc Porphyrin (ZnPor), has been used at the University of Dayton to disrupt biofilms created by the bacterial species Pseudomonas aeruginosa. Experiments using ZnPor as a biofilm disruptor have successfully reduced the number of colonies present on multiple substrata (Patel). To further reduce biofilms presence on substrata surfaces the bacteriophage PEV2 was used prior to ZnPor treatment. This combination therapy was applied to biofilms formed on multiple substrata in a flow system to mimic Pseudomonas aeruginosa pathology in humans. Results showed that adding a bacteriophage to the treatment of biofilms significantly reduced biofilm presence.

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Undergraduate research

Embargoed until Sunday, June 23, 2120